期刊
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 159, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ejps.2021.105736
关键词
Hydroxypropyl methylcellulose; Ocular drug delivery; Ocular formulations; Eye
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [306848/2017, 421014/2018]
- Sao Paulo Research Foundation (FAPESP) [2018/13492-2]
HPMC, a cellulose ether widely used in drug formulations, is commonly employed in ocular formulations as a viscosity enhancer, gelling agent, and polymeric matrix. Its physicochemical properties facilitate local drug delivery for challenging eye anatomy barriers.
Hydroxypropyl methylcellulose (HPMC) is a cellulose ether widely used in drug formulations due to its biocompatibility, uncharged nature, solubility in water and thermoplastic behavior. Particularly for ocular and ophthalmic formulations, HPMC is applied as viscosity enhancer agent in eye drops, gelling agent in injections, and polymeric matrix in films, filaments and inserts. The different therapeutic approaches are necessary due to the complex anatomic structure of the eye. The natural ocular barriers and the low drug permeation into the circulatory system make the drug administration challenging. This review presents the eye anatomy and the usual local routes of drugs administration, which are facilitated by the physicochemical properties of HPMC. The relationship between chemical structure and physicochemical properties of HPMC is displayed. The different types of formulations (local application) including HPMC for ocular drug delivery are discussed with basis on recent literature reports and patents.
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