Severity of bronchiolitis in infants is associated with their parents' tobacco habit

The aim of this study was to investigate the effect of tobacco smoke exposure among severely pediatric ICU patients. A prospective epidemiological observational study was conducted among children with bronchiolitis younger than 2 years of age admitted to the Pediatric Intensive Care Unit of Children's University Hospital La Paz during the October 2017 to March 2018 outbreak. On admission, parents were asked whether they smoked. In children who required invasive mechanical ventilation, endotracheal aspirate was collected at the time of intubation. A total of 102 patients with bronchiolitis were studied. Among these, 14 (47%) of 30 infants whose parents smoked required invasive mechanical ventilation vs. 14 (19%) of 72 whose parents were nonsmokers (p = 0.007). Among patients on invasive mechanical ventilation, 10 (71%) of 14 infants with secondhand smoke exposure presented pulmonary bacterial superinfection vs. 3 (21%) of 14 in the unexposed (p = 0.012). Conclusion: Secondhand smoke exposure is an additional high risk for pulmonary bacterial superinfection and invasive mechanical ventilation in infants with severe acute bronchiolitis What is known: center dot Environmental tobacco smoke exposure is known to be an important risk factor for childhood lower respiratory tract infections. center dot Tobacco smoke makes structural changes in the respiratory tract and reduces the immune response. What in new: center dot Secondhand smoke exposure showed to be associated with the increased need and duration of invasive mechanical ventilation, and pediatric intensive care length of stay. center dot Tobacco smoke exposure is an additional risk factor for the presence of bacteria in the endotracheal aspirate.

Automated summary

This study found that exposure to secondhand smoke increases the risk of pulmonary bacterial superinfection and the need for invasive mechanical ventilation in severely ill infants with acute bronchiolitis. Tobacco smoke significantly impacts the risk of lower respiratory tract infections in children.