4.5 Article

Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite

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EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2021, 期 18, 页码 2713-2718

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202100326

关键词

Carboxylic acids; Esterification; Green chemistry; tert-Butyl nitrite

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This study has successfully developed the green esterification of carboxylic acids promoted by tert-butyl nitrite, which is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids can be applied to this reaction under near neutral conditions, with good to excellent yields.
In this work, the green esterification of carboxylic acids promoted by tert-butyl nitrite has been well developed. This transformation is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids are applicable to this reaction under near neutral conditions, with good to excellent yields.

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