Study of Rhodamine-Based Fluorescent Probes for Organic Radical Intermediates

Rhodamine-based amide derivatives for the detection of radical intermediates in organic reactions were synthesized and used as fluorescent probes over a wide range of solvents. The mechanistic studies confirm a reversible opening and closing of the spirolactam ring. Compound 21 can be used to support the radical mechanism or in the real-time monitoring of radical intermediates.

Automated summary

Rhodamine-based amide derivatives were synthesized for detecting radical intermediates in organic reactions and used as fluorescent probes in various solvents. Mechanistic studies verified the reversible opening and closing of the spirolactam ring. Compound 21 can be employed to support the radical mechanism or for real-time monitoring of radical intermediates.