Ring Expansion to 8-Membered Silacycles through Formal Cross-Dimerization of 5-Membered Palladacycles with Silacyclobutanes

Investigations of the sila-8-membered ring fused biaryls are of high significance for the discovery of new drug lead compounds. However, such compounds are still unknown due to the synthetic challenge. Herein, we describe the chemo- and regio-selective cross-dimerization of 5-membered palladacycles with silacyclobutanes enabled by Pd-catalytic conditions, which constitutes an expedient ring expansion route to the sila-8-membered ring fused biaryl skeletons.

Automated summary

The paper discusses the significance of investigating sila-8-membered ring fused biaryls for the discovery of new drug lead compounds. It presents a method for synthesizing these compounds through chemo- and regio-selective cross-dimerization of 5-membered palladacycles with silacyclobutanes under Pd-catalytic conditions. This method provides an efficient route for ring expansion to create the desired sila-8-membered ring fused biaryl skeletons.