Asymmetric Organocatalysis in Deep Eutectic Solvents

The recent advances in asymmetric organocatalysis using eutectic mixtures as a reaction medium are revised in this mini-review. In addition, the first enantioselective transformations using chiral eutectic solvents, which play the role of a green medium and organocatalyst, are described. In this minireview we intend to deepen not only in the synthetic aspects of asymmetric organocatalysis in eutectic mixtures, but also in the fundamental issues that seem to be essential for a successful development of this promising, and at the same time challenging, methodology.

Automated summary

This mini-review summarizes recent advances in asymmetric organocatalysis using eutectic mixtures as a reaction medium, as well as the first enantioselective transformations using chiral eutectic solvents. The review aims to delve deep into both the synthetic aspects of asymmetric organocatalysis in eutectic mixtures and the fundamental issues crucial for the successful development of this promising yet challenging methodology.