4.7 Review

An insight on medicinal aspects of novel HIV-1 capsid protein inhibitors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Microbiology

Absence of Lenacapavir (GS-6207) Phenotypic Resistance in HIV Gag Cleavage Site Mutants and in Isolates with Resistance to Existing Drug Classes

Nicolas Margot et al.

Summary: LEN is a potent inhibitor of HIV-1 capsid and has shown strong antiviral response in mutants with Gag cleavage site mutations and resistance to other drug classes. While LEN demonstrated wild-type susceptibility, reduced susceptibility was observed for control drugs.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

Article Biochemistry & Molecular Biology

Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment

Kohei Tsuji et al.

Summary: Several potential anti-HIV agents have been identified based on fragment peptides libraries containing octa-arginyl residues that cover the whole sequence of an HIV-1 capsid protein. Derivatives of potent CA-19L peptide overlapping with the Helix 9 region of the CA protein were synthesized, showing promising anti-HIV activity. These new compounds may provide valuable insights into the functions of CA proteins.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

Article Infectious Diseases

Long-acting drugs and formulations for the treatment and prevention of HIV infection

Charles Flexner et al.

Summary: Long-acting and extended-release formulations are crucial for improving the treatment and prevention of chronic HIV infection. Strategies to manage toxicity, resistance, and falling drug concentrations are important considerations, with integrase inhibitors and broadly-neutralising monoclonal antibodies showing promising efficacy.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

Article Biochemistry & Molecular Biology

Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment

Kohei Tsuji et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2020)

Editorial Material Chemistry, Medicinal

Medicinal chemistry strategies of targeting HIV-1 capsid protein for antiviral treatment

Shujing Xu et al.

FUTURE MEDICINAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Clinical targeting of HIV capsid protein with a long-acting small molecule

John O. Link et al.

NATURE (2020)

Article Multidisciplinary Sciences

Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro

Devin E. Christensen et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

Stephanie M. Bester et al.

SCIENCE (2020)

Review Virology

Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle

Mariia Novikova et al.

VIROLOGICA SINICA (2019)

Article Biochemistry & Molecular Biology

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

Stephen R. Yant et al.

NATURE MEDICINE (2019)

Article Chemistry, Medicinal

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library

Gaochan Wu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

Peng Zhan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Microbiology

Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication

Suzie Thenin-Houssier et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

Article Chemistry, Medicinal

Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly

Milan Kozisek et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Immunology

HIV-1 Capsid Inhibitors as Antiretroviral Agents

Suzie Thenin-Houssier et al.

CURRENT HIV RESEARCH (2016)

Article Virology

HIV-1 capsid is involved in post-nuclear entry steps

Nan-Yu Chen et al.

RETROVIROLOGY (2016)

Review Microbiology

HIV-1 assembly, release and maturation

Eric O. Freed

NATURE REVIEWS MICROBIOLOGY (2015)

Article Multidisciplinary Sciences

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

Akash Bhattacharya et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Virology

Roles of HIV-1 capsid in viral replication and immune evasion

Valerie Le Sage et al.

VIRUS RESEARCH (2014)

Article Biochemical Research Methods

A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization

Christopher T. Lemke et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2013)

Article Microbiology

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

Louie Lamorte et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

Article Virology

HIV-1 entry inhibitors: recent development and clinical use

Timothy J. Henrich et al.

CURRENT OPINION IN VIROLOGY (2013)

Review Microbiology

Antiviral Drug Resistance and the Need for Development of New HIV-1 Reverse Transcriptase Inhibitors

Eugene L. Asahchop et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

Article Chemistry, Medicinal

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

Lee D. Fader et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Microbiology

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

Wade S. Blair et al.

PLOS PATHOGENS (2010)

Article Biochemistry & Molecular Biology

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

Owen Pornillos et al.

Article Biochemistry & Molecular Biology

A cell-penetrating helical peptide as a potential HIV-1 inhibitor

Hongtao Zhang et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1CA protein

Brian N. Kelly et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Structure of full-length HIV-1CA: a model for the mature capsid lattice

Barbie K. Ganser-Pornillos et al.

Article Biochemistry & Molecular Biology

A peptide inhibitor of HIV-1 assembly in vitro

J Sticht et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Antiviral inhibition of the HIV-1 capsid protein

C Tang et al.

JOURNAL OF MOLECULAR BIOLOGY (2003)