An insight on medicinal aspects of novel HIV-1 capsid protein inhibitors

A capsid is the protein shell of a virus, encircling its genetic material. The HIV capsid is erected from a single protein, known as capsid protein. The capsid of HIV-1 significantly involved in many processes of the virus life cycle, which makes it as a novel target for the new inhibitors. Recently many novel HIV-1 inhibitors binding to capsid proteins have been reported successfully. Most of these inhibitors can inhibit or accelerate the disassembly or assembly of the capsid, and some of them can inhibit reverse transcription. Unfortunately, none of them are currently approved by U.S. FDA. However, GS-6207, an inhibitor binds to the NTD-CTD interface with potent antiviral activity and the long metabolic cycle, is expected to be the first approved drug targeting HIV-1 capsid. Herein, we provide a concise report focusing on the recent prospective of HIV-1 capsid inhibitors in medicinal chemistry in order to enlighten drug design. (C) 2021 Elsevier Masson SAS. All rights reserved.

Automated summary

The capsid of HIV-1, composed of a protein called capsid protein, plays a significant role in the virus life cycle and is a target for new inhibitors. Novel HIV-1 inhibitors binding to capsid proteins have been developed successfully, with some expected to be approved drugs.