Half a century of immunological discovery: EJI celebrates its golden anniversary!

Article Immunology

The association of Epstein-Barr virus infection with CXCR3+ B-cell development in multiple sclerosis: impact of immunotherapies

Jamie van Langelaar et al.

Summary: The study found that EBV infection in B cells can lead to the preferential infiltration of CXCR3(+) B cells into the central nervous system in MS patients. Research on transplant recipients and MS patients treated with natalizumab indicated that EBV infection enhances antibody production and brain-homing B cell subsets.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Article Immunology

PD-1-specific Blocking antibodies that deplete PD-1+ T cells present an inconvenient variable in preclinical immunotherapy experiments

Fanny Polesso et al.

Summary: Therapeutic antibodies blocking PD-1/PD-L1 interaction have shown success in cancer treatment, but different antibody isotypes and species can impact the outcome. This study demonstrates that anti-PD-1 therapy in mice may lead to unintended target cell depletion and emphasizes the importance of considering antibody clones in experimental design and interpretation. Competing anti-PD-1 clones can be used to detect PD-1-expressing cells despite the presence of blocking antibodies, providing valuable insights for future studies.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Review Immunology

Resolving trained immunity with systems biology

Valerie A. C. M. Koeken et al.

Summary: Trained immunity involves long-term functional reprogramming of innate immune cells, leading to enhanced responsiveness to pathogens or microbial ligands. Investigating the molecular mechanisms underlying trained immunity through various layers of information using a systems biology approach can help understand the complex interplay between molecular layers and individual variation.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Review Immunology

Multiomics uncovers developing immunological lineages in human

Emily Stephenson et al.

Summary: The development of human immune system during embryonic and fetal life has historically been challenging to research due to limited access to human tissue. However, the emergence of single-cell multiomic technologies and an increase in human developmental tissue biobank resources have enabled in-depth studies on human immune development. The combined power of multiomics technologies can help address specific immunological gaps in current knowledge and explore new research horizons in human development.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Article Immunology