4.6 Review

Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update

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Summary: Pathological eye involvement is common in autoimmune rheumatic diseases, with ocular signs ranging from mild dry eye disease to sight-threatening pathologies. Prompt diagnosis and treatment are necessary for retinovascular damage driven by inflammatory reactivity, which plays a key role in systemic lupus erythematosus, rheumatoid arthritis, and Sjögren’s syndrome. Early alterations in retinal and choroidal vessels may indicate widespread vascular injury in other connective tissue diseases. Immuno-pathophysiological mechanisms of ocular microcirculatory damage associated with major ARDs will be further discussed.

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