期刊
EPILEPSY & BEHAVIOR
卷 117, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2021.107834
关键词
MRI; Language; Hippocampus; Temporal lobe epilepsy; Functional connectivity
资金
- National Institute of Neurological Disorders and Stroke [R01 NS075270, R01 NS108445, R01 NS110130, R00 NS097618, F31 NS106735]
- National Institute of Biomedical Imaging and Bioengineering [T32 EB001628, T32 EB021937]
- National Institute of General Medical Sciences [T32 GM007347]
This study used resting-state functional connectivity measures to assess hippocampal network patterns and their relation to language abilities in patients with right TLE, left TLE, and healthy controls, finding significant impact on hippocampal-temporo-parietal networks relevant to language processing in TLE patients.
Objective: Patients with temporal lobe epilepsy (TLE) commonly experience a broad range of language impairments. These deficits are thought to arise from repeated seizure activity that damages language regions. However, connectivity between the seizure onset region in the hippocampus and regions related to language processing has rarely been studied, and could also have a strong impact on language function. The purpose of this study was to use resting-state functional connectivity (FC) measures to assess hippocampal network patterns and their relation to language abilities in patients with right TLE (RLTE), left TLE (LTLE), and healthy controls. Methods: Presurgical resting-state 3T functional MRI data were acquired from 40 patients with mesial TLE (27 RTLE, 13 LTLE) and 54 controls. The regions of interest were the anterior and posterior bilateral hippocampi and eleven regions grouped by frontal or temporo-parietal locations, including large areas of language-related cortex. FC values were computed with the right/left anterior and posterior hippocampi as the seeds and frontal and temporo-parietal regions as targets. Resting-state lateralization indices were also calculated (LI-Rest), and all FC measures were correlated to neuropsychological language scores and measures related to manifestation of epilepsy including age of onset, duration of disease, monthly seizure frequency, and hippocampal volume. Results: We found significant group differences between the anterior hippocampi and temporo-parietal regions closest to the seizure focus, in which RTLE and LTLE showed stronger connectivity to their contralateral hippocampus, while controls showed similar connectivity to both hippocampi. In addition, LI-Rest demonstrated significantly more right lateralization in LTLE compared to RTLE for temporo-parietal regions only. In LTLE, we found significant associations between stronger hippocampal network resting-state FC and later age of onset and decreased left anterior hippocampal volume. Significance: The results of our study indicate that the presence of TLE impacts hippocampal-temporo-parietal networks relevant to language processing. (C) 2021 Elsevier Inc. All rights reserved.
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