期刊
ENVIRONMENTAL TOXICOLOGY
卷 36, 期 8, 页码 1521-1535出版社
WILEY
DOI: 10.1002/tox.23149
关键词
AChE; caspase‐ 3; emamectin benzoate; GABA; Nigella sativa oil
资金
- Taif University [TURSP2020/92]
The study demonstrated that Nigella sativa oil (NSO) has a protective effect against emamectin benzoate (EMB) induced neurotoxicity through its antioxidant, anti-inflammatory, and anti-apoptotic activities. The findings suggest NSO as a potential therapeutic agent for EMB-induced neurotoxicity.
This study evaluated the ameliorative impact of Nigella sativa oil (NSO) on emamectin benzoate (EMB) neurotoxicity. Thirty-five male rats were randomly allocated into 5 groups (n = 7). G1 (control): received distilled water; G2: received NSO (3 ml. Kg(-1) B.W.) for 6 weeks; G3: received EMB (9 mg kg(-1) B.W.) for 6 weeks; G4: was co-treated with NSO and EMB for 6 weeks; G5: was treated with EMB for 4 weeks then, received NSO for 2 weeks. All treatments were given orally every other day. EMB increased serum urea, creatinine levels; brain dopamine, serotonin, malondialdehyde levels; brain expression levels of caspase 3 and TNF-alpha. While, it decreased serum total protein, albumin, brain GABA, AChE, GSH-Px, CAT, and SOD levels. Histopathological findings revealed hemorrhage, congestion, severe degeneration, and edema of the brain tissues. NSO reversed the EMB-induced biochemical and histopathological alterations. This NSO effect is mostly due to its antioxidant, antiinflammatory, and antiapoptotic activities. These findings suggest NSO as a potential protective and therapeutic agent for EMB-induced neurotoxicity.
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