4.7 Article

Exposure of tilapia (Oreochromis niloticus) to the antibiotic florfenicol in water: determination of the bioconcentration factor and the withdrawal period

期刊

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 28, 期 29, 页码 39026-39034

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s11356-021-13327-5

关键词

Florfenicol amine; Bioconcentration; Withdrawal period; Oreochromis; Residues; Antibiotics

资金

  1. National Bank for Economic and Social Development (BNDES) [0117020010606007]
  2. Brazilian Agricultural Research Corporation (Embrapa) [0117020010606007]
  3. INCT/Bioanalitica/FAPESP [2014/50867-3]
  4. CNPq [311671/2015-2]
  5. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brasil) [001]
  6. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [14/50867-3] Funding Source: FAPESP

向作者/读者索取更多资源

The study assessed the accumulation of florfenicol in tilapia muscles, showing rapid absorption and elimination of the antibiotic with low potential for accumulation. Results contribute to establishing protocols for the safe use of florfenicol in tilapia transport, avoiding residues that may pose risks to human health.
The demand for healthier foods with high nutritional value has resulted in intensive fish farming. In this production system, high-frequency infections occur, and antibiotics are administrated for control. Only two antibiotics are allowed for use in Brazilian aquaculture, one of which is florfenicol. In this work, a bioconcentration assay was performed to assess the accumulation of florfenicol in the muscle of Nile tilapia (Oreochromis niloticus). Tilapia was evaluated as it is the most produced fish species in Brazil. The fish were exposed to florfenicol at a nominal concentration of 10 mg/L, through the water. Muscle and water were collected at 0, 1.5, 3, 6, 24, and 48 h during the exposure phase and at 1.5, 3, 6, 24, 48, and 120 h during the depuration phase. Quantification was performed using an LC-MS/MS. The results showed rapid absorption and elimination of the antibiotic (half-life, t(1/2) = 5 h), with low potential for accumulation of florfenicol in tilapia muscles. The study was performed to determine the bioconcentration factor (BCF) and withdrawal period of florfenicol, being 0.05 mL/mu g and 1.8 h, respectively. The results contribute to set protocols for the safe use of florfenicol in tilapia transport, avoiding residues in fish that may pose risks to human health.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据