4.5 Review

Obesity: Overview of Weight Management

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Summary: Endoscopic bariatric and metabolic treatments (EBMTs) have been developed to combat the increasing prevalence of obesity, with FDA-approved and non-approved treatments available, including various devices and procedures such as intragastric balloons, aspiration therapy, and endoscopically placed anastomosis devices.

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Patterns of Weight Loss Medication Utilization and Outcomes Following Bariatric Surgery

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Summary: This study found that patients who underwent Roux-en-Y gastric bypass surgery had greater weight loss compared to those who had sleeve gastrectomy. Patients who started weight loss medications early and used them during weight plateau experienced greater overall weight loss. Phentermine + topiramate was found to be the most effective weight loss medication for post-bariatric surgery patients.

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Once-Weekly Semaglutide in Adults with Overweight or Obesity

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Summary: The study demonstrates that for individuals with obesity, once-weekly use of 2.4 mg semaglutide in combination with lifestyle intervention can lead to sustained and clinically relevant weight loss, with significant improvements in cardiometabolic risk factors and physical functioning reported by participants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Approach to the Patient: Management of the Post-Bariatric Surgery Patient With Weight Regain

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Summary: This study presents a practical approach for early recognition of weight regain after bariatric surgery, including classification and treatment options. Emphasizing the importance of regular long-term follow-up for all bariatric surgery patients.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Exercise for Weight Loss: Further Evaluating Energy Compensation with Exercise

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NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Processed foods and food reward

Dana M. Small et al.

SCIENCE (2019)

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Remotely Delivered Interventions for Obesity Treatment

Lauren E. Bradley et al.

CURRENT OBESITY REPORTS (2019)

Article Public, Environmental & Occupational Health

Pathways to ethnic differences in obesity: The role of migration, culture and socio-economic position in the UK

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SSM-POPULATION HEALTH (2019)

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Current pharmacotherapy for obesity

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Role of Physical Activity and Exercise in Treating Patients with Overweight and Obesity

John M. Jakicic et al.

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Intensive Lifestyle Intervention for Obesity: Principles, Practices, and Results

Victoria L. Webb et al.

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Web-Based Interventions for Weight Loss or Weight Loss Maintenance in Overweight and Obese People: A Systematic Review of Systematic Reviews

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Bariatric Surgery versus Intensive Medical Therapy for Diabetes-5-Year Outcomes

Philip R. Schauer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Mechanisms, Pathophysiology, and Management of Obesity

Steven B. Heymsfield et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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The burden of obesity in the current world and the new treatments available: focus on liraglutide 3.0 mg

Marcio C. Mancini et al.

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Off-label drugs for weight management

Ed J. Hendricks

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Article Gastroenterology & Hepatology

Endoscopic sleeve gastroplasty: the learning curve

Christine Hill et al.

ENDOSCOPY INTERNATIONAL OPEN (2017)

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Endoscopic Bariatric and Metabolic Therapies: Surgical Analogues and Mechanisms of Action

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CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2017)

Review Medicine, General & Internal

Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events A Systematic Review and Meta-analysis

Rohan Khera et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Review Medicine, General & Internal

Adiposopathy and epigenetics: an introduction to obesity as a transgenerational disease

Harold Bays et al.

CURRENT MEDICAL RESEARCH AND OPINION (2015)

Article Endocrinology & Metabolism

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations

Kristin I. Stanford et al.

DIABETES (2015)

Article Endocrinology & Metabolism

Pharmacological Management of Obesity: An Endocrine Society Clinical Practice Guideline

Caroline M Apovian et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Review Endocrinology & Metabolism

Review of Innovations in Digital Health Technology to Promote Weight Control

J. Graham Thomas et al.

CURRENT DIABETES REPORTS (2014)

Review Medicine, General & Internal

Long-term Drug Treatment for Obesity A Systematic and Clinical Review

Susan Z. Yanovski et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

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Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight

Laurie L. Baggio et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Review Medicine, General & Internal

Bariatric surgery for obesity and metabolic conditions in adults

David E. Arterburn et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

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Diet or Exercise Interventions vs Combined Behavioral Weight Management Programs: A Systematic Review and Meta-Analysis of Direct Comparisons

David J. Johns et al.

JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS (2014)

Review Medicine, General & Internal

Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories A Systematic Review and Meta-analysis

Katherine M. Flegal et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Article Pharmacology & Pharmacy

Use of Prescription Antiobesity Drugs in the United States

Christian Hampp et al.

PHARMACOTHERAPY (2013)

Article Public, Environmental & Occupational Health

Race, Place, and Obesity: The Complex Relationships Among Community Racial/Ethnic Composition, Individual Race/Ethnicity, and Obesity in the United States

James B. Kirby et al.

AMERICAN JOURNAL OF PUBLIC HEALTH (2012)

Article Medicine, General & Internal

Zonisamide for Weight Reduction in Obese Adults A 1-Year Randomized Controlled Trial

Kishore M. Gadde et al.

ARCHIVES OF INTERNAL MEDICINE (2012)

Article Cardiac & Cardiovascular Systems

Medical Therapy for the Patient With Obesity

George A. Bray et al.

CIRCULATION (2012)

Article Cardiac & Cardiovascular Systems

Food and Drug Administration's Obesity Drug Guidance Document A Short History

Eric Colman

CIRCULATION (2012)

Review Endocrinology & Metabolism

Regulation of Food Intake, Energy Balance, and Body Fat Mass: Implications for the Pathogenesis and Treatment of Obesity

Stephan J. Guyenet et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Article Cardiac & Cardiovascular Systems

Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06

Genevieve N. Healy et al.

EUROPEAN HEART JOURNAL (2011)

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Regulation of appetite to treat obesity

Gilbert W Kim et al.

Expert Review of Clinical Pharmacology (2011)

Review Endocrinology & Metabolism

Relative changes in resting energy expenditure during weight loss: a systematic review

A. Schwartz et al.

OBESITY REVIEWS (2010)

Article Medicine, General & Internal

Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates.

Frank M. Sacks et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Orlistat-associated adverse effects and drug interactions - A critical review

Theodosios D. Filippatos et al.

DRUG SAFETY (2008)

Article Endocrinology & Metabolism

Central and Peripheral Regulation of Food Intake and Physical Activity: Pathways and Genes

Natalie R. Lenard et al.

OBESITY (2008)

Article Medicine, General & Internal

Body weight changes with β-blocker use:: Results from GEMINI

Franz H. Messerli et al.

AMERICAN JOURNAL OF MEDICINE (2007)

Review Genetics & Heredity

The genetics of human obesity

CG Bell et al.

NATURE REVIEWS GENETICS (2005)

Article Medicine, General & Internal

Comparison of the Atkins, Ornish, Weight watchers, and Zone diets for weight loss and heart disease risk reduction

ML Dansinger et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

Review Endocrinology & Metabolism

Weight management using a meal replacement strategy: meta and pooling analysis from six studies

SB Heymsfield et al.

INTERNATIONAL JOURNAL OF OBESITY (2003)

Article Medicine, General & Internal

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

WC Knowler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)