期刊
ENDOCRINE PRACTICE
卷 27, 期 9, 页码 934-940出版社
ELSEVIER INC
DOI: 10.1016/j.eprac.2021.05.004
关键词
bone mineral density; male idiopathic hypogonadotropic hypogonadism; sex hormone replacement therapy
资金
- Project of National Natural Science Foundation of China [81771576, 81971375]
- Beijing Municipal Natural Science Foundation [7202151, 7212080]
Sex hormone therapy improves hip and lumbar spine bone mineral density in patients with IHH, with a greater improvement seen in lumbar spine BMD.
Objective: This retrospective observational study assessed the long-term impact of pulsatile gonadotropin-releasing hormone, combined gonadotropin, or testosterone replacement therapy on total hip, femoral, and lumbar bone mineral density (BMD) and Z-scores in adult men with idiopathic hypogonadotropic hypogonadism (IHH). Methods: In the cross-sectional study, 69 patients were allocated to untreated (n = 42) and treated (n = 27) groups. The untreated group included IHH patients without hormone therapy history, while the treated group included age- and body mass index-matched patients who had received hormone therapy for at least 5 years. The longitudinal study included 53 IHH patients, and their hip and lumbar BMDs were measured several times during hormone therapy. We then evaluated the changes in their BMD. Results: Our cross-sectional study showed that the treated group had a significantly higher BMD and Z-score for total hip, femoral neck, and lumbar spine (P < 0.001 for all) than the untreated group, and the average bone mass even reached the age-matched normal range. The prevalence of low BMD was 80.95% and 11.11% in untreated and treated groups, respectively. In the longitudinal study (N = 53), the total hip, femoral neck, and lumbar spine BMD gradually increased during treatment. The lumbar spine showed a greater increment in BMD compared with the total hip and femoral neck (P < 0.05). Conclusion: Sex hormone therapy improved hip and lumbar spine BMD and Z-scores in patients with IHH. The lumbar spine showed a greater improvement in BMD compared with the total hip and femoral neck. (C) 2021 Published by Elsevier Inc. on behalf of the AACE.
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