期刊
ELECTROPHORESIS
卷 42, 期 21-22, 页码 2375-2382出版社
WILEY
DOI: 10.1002/elps.202000357
关键词
Acoustofluidics; 3D patterning; Lab‐ on‐ chip; Microfluidics; Surface acoustic waves
资金
- Nanyang Technological University
- Ministry of Education of Singapore
- Academic Research Fund (AcRF) Tier 1 Grants [RG 96/18]
This study successfully manipulated the orientation and curvature of 3D matrix pattern by redesigning the top wall of microfluidic chamber, and created a 3D longitudinal pattern along preinserted PDMS rods. The research has the potential to contribute to the development of better organs-on-chips platforms and suitable for self-assembling of microvasculatures.
Reconstructing of cell architecture plays a vital role in tissue engineering. Recent developments of self-assembling of cells into three-dimensional (3D) matrix pattern using surface acoustic waves have paved a way for a better tissue engineering platform thanks to its unique properties such as nature of noninvasive and noncontact, high biocompatibility, low-power consumption, automation capability, and fast actuation. This article discloses a method to manipulate the orientation and curvature of 3D matrix pattern by redesigning the top wall of microfluidic chamber and the technique to create a 3D longitudinal pattern along preinserted polydimethylsiloxane (PDMS) rods. Experimental results showed a good agreement with model predictions. This research can actively contribute to the development of better organs-on-chips platforms with capability of controlling cell architecture and density. Meanwhile, the 3D longitudinal pattern is suitable for self-assembling of microvasculatures.
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