期刊
ELECTROANALYSIS
卷 34, 期 2, 页码 397-404出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.202100063
关键词
PB− Au@MoS2 hybrid; Aptasensor; Electrochemical detection; Thrombin
资金
- National Natural Science Foundation of China [21605113]
- National Innovation Training Program of Undergraduates [201810060046]
The electrochemical aptasensor constructed based on PB-Au@MoS2 demonstrated excellent performance for thrombin detection, with a detection linear range from 0.01 pM to 30 nM and a detection limit down to 1 fM. This work may offer a strategy to develop effective and sensitive sensing devices for thrombin in clinical diagnosis.
Human serum is one of the effective samples for point-of-care testing (POCT). Sensitive and quick determination of thrombin content in human serum samples is important. An electrochemical aptasensor based on Prussian blue and Au nanoparticles loaded MoS2 nanoflowers (PB-Au@MoS2) hybrid was constructed. By using PB-Au@MoS2 as both a substrate and a signal reporter, this aptasensor could demonstrate excellent performance for thrombin detection with a detection linear range from 0.01 pM to 30 nM and detection limit down to 1 fM. This work may provide a strategy to establish effective and sensitive sensing devices for thrombin in clinical diagnosis.
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