Sortase A (SrtA) inhibitors as an alternative treatment for superbug infections

Virulence factor, sortase A (SrtA), has crucial roles in the pathogenesis of Gram-positive superbugs. SrtA is a bacterial cell membrane enzyme that anchors crucial virulence factors to the cell wall surface of Gram-positive bacteria. SrtA is not necessary for bacterial growth and viability and is conveniently accessible in the cell membrane; therefore, it is an ideal target for antivirulence drug development. In this review, we focus on antimicrobial resistance (AMR)-expressing bacteria and SrtA as a potential target for overcoming AMR. The mechanism of action of SrtA and its inhibition by various types of inhibitors, such as synthetic small molecules, peptides, and natural products, are provided. Future SrtA research perspectives for alternative drug development to antibiotics are also proposed.

Automated summary

Virulence factor SrtA plays a crucial role in the pathogenesis of Gram-positive superbugs and is an ideal target for antivirulence drug development. Inhibitors targeting SrtA, including synthetic small molecules, peptides, and natural products, show promise in overcoming antimicrobial resistance (AMR) in bacteria expressing AMR. Future research on SrtA may lead to alternative drug development strategies in the face of antibiotic resistance.