期刊
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
卷 497, 期 1, 页码 66-70出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1607672921020095
关键词
colorectal cancer; blood serum; expression; PD-1; PD-L1; IDO1
资金
- Russian Foundation for Basic Research [20-015-00479]
A comprehensive study on the expression of soluble and tissue forms of PD-1, PD-L1, and IDO1 in blood serum and tumors of CRC patients was conducted, revealing independent mechanisms of immunosuppression in CRC which may explain the inefficacy of immunotherapy for this type of tumor.
Due to the low efficiency of immunotherapy for colorectal cancer (CRC), it is extremely promising and relevant to study the mechanisms of immunosuppression. In this work, a comprehensive study of the expression of soluble and tissue forms of PD-1 and PD-L1 in blood serum and tumors of patients with CRC, as well as IDO1 in tumors was performed for the first time. The diagnostic and prognostic significance of the studied parameters was determined. A statistically significant decrease in the number of soluble forms of PD-1 and PD-L1 in the blood serum and the association of the number of PD-L1+ cells in the stroma of tumors with the CRC stage were established. The absence of correlations between soluble and tissue forms of the studied proteins was shown, indicating the presence of independent mechanisms of immunosuppression in CRC, which may explain the ineffectiveness of immunotherapy for this type of tumor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据