Mechanisms of Ferroptosis and Application to Head and Neck Squamous Cell Carcinoma Treatments

Many kinds of cancer cells are intrinsically sensitive to ferroptosis, and research interest regarding ferroptosis has been sparked by its significant role in many detrimental diseases. Ferroptosis is a novel type of iron-dependent cell death mediated by accumulation of reactive oxygen species and lipid peroxidation. Furthermore, a large number of small agents can induce ferroptosis in numerous kinds of cancer cells, including prostate cancer, pancreatic cancer, breast cancer, lymphomas, and renal cancer. These insights may help discover novel approaches for cancer therapeutic strategies; however, there is considerable uncertainty regarding ferroptosis in head and neck cancer (HNC). So far, no review of the current studies on this topic has been published. Therefore, we here elaborate the mechanisms of ferroptosis and summarize the latest findings regarding its role in HNC according to current literature. The respective findings shed light on the role of ferroptosis in HNC treatment with a number of important implications for future practice in HNC management, as outlined in this review.

Automated summary

Ferroptosis, a novel type of iron-dependent cell death, plays a significant role in inducing cancer cell death through the accumulation of reactive oxygen species and lipid peroxidation. However, there is considerable uncertainty regarding the role of ferroptosis in head and neck cancer, and no review of current studies on this topic has been published so far.