期刊
DNA AND CELL BIOLOGY
卷 40, 期 6, 页码 713-719出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2020.6453
关键词
COVID-19; SARS-CoV; coronavirus; interferon; mitochondria; oxidative stress
COVID-19 is the worst public health crisis of the century, with mitochondria playing an important role in its pathogenesis and affecting the prognosis of patients with obesity, metabolic syndrome, or type 2 diabetes.
Coronavirus disease 2019 (COVID-19) is the worst public health crisis of the century. Although we have made tremendous progress in understanding the pathogenesis of this disease, a lot more remains to be learned. Mitochondria appear to be important in COVID-19 pathogenesis because of its role in innate antiviral immunity, as well as inflammation. This article examines pathogenesis of COVID-19 from a mitochondrial perspective and tries to answer some perplexing questions such as why the prognosis is so poor in those with obesity, metabolic syndrome, or type 2 diabetes. Although effective vaccines and antiviral drugs will be the ultimate solution to this crisis, a better understanding of disease mechanisms will open novel avenues for treatment and prevention.
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