Uncovering Pathways to Personalized Therapies in Type 1 Diabetes

The goal of personalized medicine is to match the right drugs to the right patients at the right time. Personalized medicine has been most successful in cases where there is a clear genetic linkage between a disease and a therapy. This is not the case with type 1 diabetes (T1D), a genetically complex immune-mediated disease of beta-cell destruction. Researchers over decades have traced the natural history of disease sufficiently to use autoantibodies as predictive biomarkers for disease risk and to conduct successful clinical trials of disease-modifying therapy. Recent studies, however, have highlighted heterogeneity associated with progression, with nonuniform rate of insulin loss and distinct features of the peri-diagnostic period. Likewise, there is heterogeneity in immune profiles and outcomes in response to therapy. Unexpectedly, from these studies demonstrating perplexing complexity in progression and response to therapy, new biomarker-based principles are emerging for how to achieve personalized therapies for T1D. These include therapy timed to periods of disease activity, use of patient stratification biomarkers to align therapeutic target with disease endotype, pharmacodynamic biomarkers to achieve personalized dosing and appropriate combination therapies, and efficacy biomarkers for treat-to-target strategies. These principles provide a template for application of personalized medicine to complex diseases.

Automated summary

The goal of personalized medicine is to match the right drugs to the right patients at the right time. However, for complex diseases like type 1 diabetes, personalized therapy should consider factors such as treatment timing, patient stratification, pharmacodynamic biomarkers, and efficacy biomarkers. Research in personalized medicine for type 1 diabetes is providing insights for achieving personalized therapies for other complex diseases.