4.3 Review

Tools and approaches for analyzing the role of mitochondria in health, development and disease using human cerebral organoids

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Summary: The study developed cerebral organoids (COs) from induced pluripotent stem cells (iPSCs) derived from human peripheral blood mononuclear cells (PBMCs) and monitored mitochondrial health from the primary, reprogrammed and differentiated stages. Results show preserved mitochondrial genetics, function and treatment responses throughout the process, with measurable neuronal activity in the COs.

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