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Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Stanley Ching-Cheng Huang et al.
NATURE IMMUNOLOGY (2014)
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
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NATURE MEDICINE (2014)
Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment
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TRENDS IN CELL BIOLOGY (2014)
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
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From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation
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FRONTIERS IN IMMUNOLOGY (2014)
Cancer cachexia: understanding the molecular basis
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NATURE REVIEWS CANCER (2014)
Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
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CANCER CELL (2013)
An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
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CANCER RESEARCH (2013)
Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma
Christina A. von Roemeling et al.
CLINICAL CANCER RESEARCH (2013)
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
Regina M. Young et al.
GENES & DEVELOPMENT (2013)
Towards Lipidomics of Low-Abundant Species for Exploring Tumor Heterogeneity Guided by High-Resolution Mass Spectrometry Imaging
Jonathan Cimino et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade
Bang-Bao Tao et al.
JOURNAL OF CLINICAL NEUROSCIENCE (2013)
AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism
Stephen L. Pinkosky et al.
JOURNAL OF LIPID RESEARCH (2013)
Carnitine-Acyltransferase System Inhibition, Cancer Cell Death, and Prevention of Myc-Induced Lymphomagenesis
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)
Comprehensivemolecular characterization of clear cell renal cell carcinoma
Chad J. Creighton et al.
NATURE (2013)
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
Yoko Kidani et al.
NATURE IMMUNOLOGY (2013)
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
Jurre J. Kamphorst et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Risk of colorectal cancer after initiation of orlistat: matched cohort study
Jin-Liern Hong et al.
BMJ-BRITISH MEDICAL JOURNAL (2013)
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
Beatrice Griffiths et al.
CANCER & METABOLISM (2013)
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas
F. Seguin et al.
BRITISH JOURNAL OF CANCER (2012)
Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma
Pilar Caro et al.
CANCER CELL (2012)
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon et al.
CELL (2012)
Regulation of Immune Responses by Prostaglandin E-2
Pawel Kalinski
JOURNAL OF IMMUNOLOGY (2012)
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and-2
Jenson Qi et al.
JOURNAL OF LIPID RESEARCH (2012)
Metabolic checkpoints in activated T cells
Ruoning Wang et al.
NATURE IMMUNOLOGY (2012)
Inhibition of Fatty Acid Metabolism Reduces Human Myeloma Cells Proliferation
Jose Manuel Tirado-Velez et al.
PLOS ONE (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Free Radical Lipid Peroxidation: Mechanisms and Analysis
Huiyong Yin et al.
CHEMICAL REVIEWS (2011)
Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma
Diego F. Calvisi et al.
GASTROENTEROLOGY (2011)
Lipid Raft Localization of EGFR Alters the Response of Cancer Cells to the EGFR Tyrosine Kinase Inhibitor Gefitinib
Mary E. Irwin et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2011)
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Ryan D. Michalek et al.
JOURNAL OF IMMUNOLOGY (2011)
Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research
Simona M. Ceccarelli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia
Renata M. Oballa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Kristin M. Nieman et al.
NATURE MEDICINE (2011)
Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion
Robert D. Schreiber et al.
SCIENCE (2011)
De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Evelien Rysman et al.
CANCER RESEARCH (2010)
Fatty acid synthase as a potential therapeutic target in cancer
Richard Flavin et al.
FUTURE ONCOLOGY (2010)
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
Ismael Samudio et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Lipid accumulation and dendritic cell dysfunction in cancer
Donna L. Herber et al.
NATURE MEDICINE (2010)
Dysregulation of the mevalonate pathway promotes transformation
James W. Clendening et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Lipid Rafts As a Membrane-Organizing Principle
Daniel Lingwood et al.
SCIENCE (2010)
Inhibition of Fatty Acid Synthase by Orlistat Accelerates Gastric Tumor Cell Apoptosis in Culture and Increases Survival Rates in Gastric Tumor Bearing Mice In Vivo
Shawn Dowling et al.
LIPIDS (2009)
ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer
Toshiro Migita et al.
CANCER RESEARCH (2008)
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir
Emma Hernlund et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
Marco A. Carvalho et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study
Christian J. F. Holubarsch et al.
CLINICAL SCIENCE (2007)
Discovery of potent, selective, orally bioavailable Stearoyl-CoA desaturase 1 inhibitors
Gang Liu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma
Svetomir N. Markovic et al.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2007)
Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake
Jeff S. Isenberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Perhexiline
Houman Ashrafian et al.
CARDIOVASCULAR DRUG REVIEWS (2007)
Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults
GC Burdge et al.
REPRODUCTION NUTRITION DEVELOPMENT (2005)
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity
SJ Kridel et al.
CANCER RESEARCH (2004)
Identification and expression of mammalian long-chain PUFA elongation enzymes
AE Leonard et al.
LIPIDS (2002)
Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
JV Swinnen et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Thrombospondins and tumor angiogenesis
F de Fraipont et al.
TRENDS IN MOLECULAR MEDICINE (2001)