期刊
DEVELOPMENTAL BIOLOGY
卷 473, 期 -, 页码 105-118出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2021.02.003
关键词
Drosophila; germline stem cells; Somatic gonadal cells; Signaling pathways; Transcription; Chromatin regulator; Epigenetics
资金
- NIH [F31GM134641]
- NIGMS/NIH [R35GM127075]
- NICHD/NIH [R01HD102474]
- Howard Hughes Medical Institute
- David and Lucile Packard Foundation
- Johns Hopkins University startup funds
The article mainly discusses the regulatory role of epigenetic mechanisms between germ cells and somatic cells on the identity and activity of germline stem cells, introducing the cellular differentiation mechanisms during gametogenesis.
Gametogenesis is one of the most extreme cellular differentiation processes that takes place in Drosophila male and female germlines. This process begins at the germline stem cell, which undergoes asymmetric cell division (ACD) to produce a self-renewed daughter that preserves its stemness and a differentiating daughter cell that undergoes epigenetic and genomic changes to eventually produce haploid gametes. Research in molecular genetics and cellular biology are beginning to take advantage of the continually advancing genomic tools to understand: (1) how germ cells are able to maintain their identity throughout the adult reproductive lifetime, and (2) undergo differentiation in a balanced manner. In this review, we focus on the epigenetic mechanisms that address these two questions through their regulation of germline-soma communication to ensure germline stem cell identity and activity.
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