期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 22, 期 6, 页码 470-478出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203722666210325110231
关键词
Synaptotagmin-1; vesicle docking; priming; fusion; exocytosis; secretory vesicles
资金
- Pharmakon Neuroscience Research Network, Dhaka, Bangladesh
This review focuses on the role of the Syt-1 protein in secretory vesicle docking, priming, and fusion. It highlights how Syt-1 acts as a Ca2+ sensor and participates in forming the docking complex to facilitate vesicle fusion with the plasma membrane.
The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca2+ sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules. Syt-1 binds to the acceptor complex such as synaxinl, SNAP-25 on the plasma membrane to facilitate secretory vesicle docking, and upon Ca2+-influx, it promotes vesicle fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking, priming, and fusion.
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