期刊
CURRENT PHARMACEUTICAL DESIGN
卷 27, 期 5, 页码 687-694出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612826666201113095720
关键词
Asphyxia neonatorum; birth asphyxia; cerebral hypoxia-ischemia; medical gas research; molecular hydrogen; neonatal animals; neuroprotectants; translational research
资金
- Hungarian Brain Research Program 2.0 [2017-2.1 NKP 2017 00002]
- EU [EFOP-3.6.1-16-2016-00008]
- [GINOP 2.3.2-15-2016-00034]
Hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in term neonates. Recent studies have shown that molecular hydrogen may have neuroprotective effects in combating the deleterious consequences of hypoxic-ischemic insults. However, further research is needed to explore the potential synergistic effect of hydrogen with therapeutic hypothermia for the treatment of HIE.
Hypoxic-ischemic encephalopathy (HIE) remains to be a major cause of morbidity, mortality and severe neurodevelopmental disability in term neonates. Moderate whole body hypothermia is an established, effective neuroprotective therapy to reduce mortality and long-term disability associated with HIE, however, research for adjunct therapies is still warranted to complement the effect of hypothermia. In the last decade, molecular hydrogen emerged as a simple, available, inexpensive substance with advantageous pharmacokinetics to ameliorate hypoxic-ischemic cellular damage. The present review examines the preclinical studies employing hydrogen to combat the deleterious consequences of hypoxic-ischemic insults in rodent and piglet HIE models. Hydrogen exerted unequivocal neuroprotective actions shown by preserved neurovascular function, neuronal viability, and neurocognitive functions in virtually all model species and hypoxic-ischemic insult types tested. Administration of hydrogen started in most studies after the hypoxic-ischemic insult enhancing the translational value of the findings. Among the explored mechanisms of hydrogen-induced neuroprotection, antioxidant, anti-apoptotic and anti-inflammatory effects appeared to be dominant. Unfortunately, the additive neuroprotective effect of hydrogen and therapeutic hypothermia has not yet been demonstrated, thus such studies are warranted to promote the clinical testing of molecular hydrogen as an adjunct neuroprotective treatment of HIE.
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