期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 23, 期 2, 页码 189-198出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201022666210405142611
关键词
Physical exercise; cognitive impairment; cognitive decline; aging; hippocampus; neurogenesis; neurotrophic factors
资金
- University Research Project Grant (PIACERI Found - NATURE-OA - 2020-2022), Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Italy
Physical exercise promotes general well-being and can prevent diseases, as well as reduce cognitive impairments and the risk of neurodegenerative diseases.
Physical exercise (PE), notoriously, promotes a state of general well-being, throughout the entire human lifespan. Moreover, maintaining an adequate and regular PE habit results in a powerful preventive factor towards many diseases and may also help in managing existing pathological conditions. PE induces structural and functional changes in various parts of the body, determining biological and psychological benefits. Additionally, in the elderly, PE might represent a remarkable tool reducing cognitive impairments related to the normal aging processes and it has also been found to have an impact on neurodegenerative diseases such as Alzheimer's disease. The present review aims to provide an overview of PE effects on the hippocampus, since it is one of the brain regions most susceptible to aging and, therefore, involved in diseases characterized by cognitive impairment.
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