期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 67, 期 -, 页码 183-189出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2020.11.014
关键词
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资金
- Swiss National Science Foundation [170672]
- European Research Council [803870]
- European Research Council (ERC) [803870] Funding Source: European Research Council (ERC)
Associative fear learning is a fundamental mechanism crucial for an animal's survival, with evidence suggesting that fear memories are acquired, stored, and modulated by a distributed neuronal network across many brain areas.
Associative fear learning is a fundamental learning mechanism that is crucial for an animal's survival. The amygdala's role in fear memory formation has been studied extensively and molecular, cell type and circuit-specific learning mechanisms as well as population level encoding of threatful stimuli within the amygdala are at the core of fear learning. Nevertheless, increasing evidence suggests that fear memories are acquired, stored and modulated by a distributed neuronal network across many brain areas. Here we review recent studies that particularly re-assessed the role of auditory/lateral thalamus, which is one synapse upstream of the lateral amygdala, required for fear learning and exhibits a striking functional resemblance and plasticity pattern to downstream amygdala neurons on the single cell level, yet distinct population level coding.
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