期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 68, 期 -, 页码 251-261出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2021.02.002
关键词
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资金
- Portuguese Foundation for Science and Technology (FCT) [UIDB/04469/2020]
- Innovative Training Networks (ITN) Marie Sklodowska-Curie Actions H2020-MSCA-ITN2018
- MICIU/AEI/FEDER, UE, Spain [813439, PID2019-105311RB-I00]
- National Science Centre of Poland (Narodowe Centrum Nauki) [2016/21/B/NZ6/01157, 2017/26/M/NZ1/00233]
The complex biofilm architecture composed of EPS provides a protective shield for bacteria. Phages have developed strategies to overcome biofilm barriers and their enzymes can combat biofilms by degrading EPS. Combining phages or phage-borne enzymes with antibiotics can achieve antibiofilm performance.
The complex biofilm architecture composed of extracellular polymeric structures (EPS) provides a protective shield to physiologically diverse bacterial cells immersed in its structure. The evolutionary interplay between bacteria and their viruses (phages) forced the latter ones to develop specific strategies to overcome the biofilm defensive barriers and kill sessile cells. Phages are equipped with a wide panel of enzyme-degrading EPS macromolecules which together are powerful weapons to combat biofilms. Antibiofilm performance can be achieved by combining phages or phage-borne enzymes with other antimicrobials such as antibiotics. Nevertheless, a variety of enzymes encoded in phage genomes still need to be explored. To advance in biofilm control strategies we must deepen the understanding of the biofilm biology itself, as well as discover and better exploit the unlimited antibacterial potential of phages.
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