期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 68, 期 -, 页码 240-250出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2021.02.003
关键词
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资金
- ALSAC
- National Multiple Sclerosis Society
- National Institutes of Health [AI105887, AI131703, AI140761, AI150241, AI150514, CA221290, CA250533]
T cells play vital roles in cancer immunity, and cellular metabolism dynamically adjusts to impact T cell function. The balance between effector T cells and T-regulatory cells is crucial for immune homeostasis.
T cells shape immune responses in cancer, autoimmunity and infection, in which CD4(+) T helper (Th) and CD8(+) T cells mediate effector responses that are suppressed by regulatory T (T-reg) cells. The balance between effector T cell and T-reg cell function orchestrates immune homeostasis and functional programming, with important contributions to the onset and progression of cancer. Cellular metabolism is dynamically rewired in T cells in response to environmental cues and dictates various aspects of T cell function. In this review, we summarize recent findings on how cellular metabolism modulates effector T cell and T-reg cell functional fitness in homeostasis and cancer immunity, and highlight the therapeutic implications of targeting immunometabolic pathways for cancer and other diseases.
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