期刊
CURRENT NEUROPHARMACOLOGY
卷 20, 期 3, 页码 476-493出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570159X19666210311104408
关键词
Non-traditional pain models; zebrafish; noxious stimuli; nociceptors; pain-related behaviors; anti-pain medication screening
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- CoordenacAo de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
- FundacAo de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- Sirius University, Sochi, Russia
This article introduces the advantages of zebrafish as a pain model and its applications in studying the mechanisms of pain response. The article also discusses the latest research advances and outlines the potential advantages and limitations of zebrafish models in studying pain behaviors and mood disorders, as well as facilitating analgesic therapy screening.
The ability of the nervous system to detect a wide range of noxious stimuli is crucial to avoid life-threatening injury and to trigger protective behavioral and physiological responses. Pain represents a complex phenomenon, including nociception associated with cognitive and emotional processing. Animal experimental models have been developed to understand the mechanisms involved in pain response, as well as to discover novel pharmacological and non-pharmacological anti-pain therapies. Due to the genetic tractability, similar physiology, low cost, and rich behavioral repertoire, the zebrafish (Danio rerio) is a powerful aquatic model for modeling pain responses. Here, we summarize the molecular machinery of zebrafish responses to painful stimuli, as well as emphasize how zebrafish-based pain models have been successfully used to understand specific molecular, physiological, and behavioral changes following different algogens and/or noxious stimuli (e.g., acetic acid, formalin, histamine, Complete Freund's Adjuvant, cinnamaldehyde, allyl isothiocyanate, and fin clipping). We also discuss recent advances in zebrafish-based studies and outline the potential advantages and limitations of the existing models to examine the mechanisms underlying pain responses from evolutionary and translational perspectives. Finally, we outline how zebrafish models can represent emergent tools to explore pain behaviors and pain-related mood disorders, as well as to facilitate analgesic therapy screening in translational pain research.
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