期刊
CURRENT MEDICINAL CHEMISTRY
卷 28, 期 34, 页码 6990-7005出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867328666210331145134
关键词
Gold nanoclusters; pharmacokinetic; photothermal therapy; bioimaging; drug delivery; radiosensitizer
资金
- National Natural Science Foundation of China [51873168, 20151j0183m]
Gold nanoclusters exhibit special physical and chemical properties, with great potential in biomedical applications, especially in cancer treatment. Recent progress has been made in the preparation, functionalization, and applications of AuNCs in tumor treatment.
As a new type of nanomaterials, the gold nanoclusters (AuNCs) perform many special physical and chemical properties, such as large Stokes shift, relatively simple preparation, good water solubility, low toxicity, and good biocompatibility, which make them show infinite potential in various fields, especially in cancer treatment. In recent years, great progress has been made in the preparation, functionalization, and biomedical applications of the AuNCs. In this article, the latest research progress and synthesis methods of the AuNCs have been summarized, emphasizing the preparation using the bottom-up synthesis strategy. Furthermore, we introduced the in vivo pharmacokinetic performance of the AuNCs. In the last part, we exemplified the applications of the AuNCs in biomedicine, including photothermal therapy (PTT), bioimaging, drug delivery, and radiotherapy sensitization, which further confirmed the great potential of the AuNCs in tumor treatment.
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