Regulating Inflammation Associated Ferroptosis- A Treatment Strategy for Parkinson Disease

Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic reasons for PD, it's underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson's disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurological disorders, including PD. We have also discussed the unique features of ferroptosis , and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis for PD pathology and inducers and inhibitors, pharmacological drugs and clinical trials for PD candidates in phase IV stage in completed status are detailed in the respective sections.

Automated summary

This review highlights the critical role of ferroptosis in various diseases and its specific mechanisms in Parkinson's disease, emphasizing the role of neuroinflammation. Personalized treatment strategies for PD pathology and relevant clinical trials are also discussed in the article.