期刊
CURRENT CANCER DRUG TARGETS
卷 21, 期 8, 页码 631-639出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568009619666210316112333
关键词
Cancer stem cells (CSCs); lipid metabolism; cancer progression; tumor microenvironment; dysregulation of lipid metabolism; energy homeostasis
类别
资金
- National Natural Science Foundation of China [81874036]
Cancer stem cells play a critical role in cancer progression, with aberrant lipid metabolism having a significant impact on disease pathogenesis.
Cancer stem cells (CSCs) represent a small population of cancer cells that are able to self-renew and initiate tumors, which undergo epigenetic, epithelial-mesenchymal, immunological, and metabolic reprogramming to adapt to the tumor microenvironment as well as survive host defense or therapeutic insults. The metabolic reprogramming that accompanies cancer onset is known to be critical for the disease pathogenesis. A coordinated dysregulation of lipid metabolism is observed in nearly all cancer types. In addition to fulfilling the basic requirements of structural lipids for membrane synthesis, lipids function importantly as signaling molecules and contribute to energy homeostasis. In this review, we summarize the current progress in the attractive research field of aberrant lipid metabolism regarding CSCs in cancer progression, which provides insights into therapeutic agents targeting CSCs based upon their modulation of lipid metabolism,
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