期刊
CURRENT BIOLOGY
卷 31, 期 11, 页码 2263-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2021.03.025
关键词
-
资金
- Recruitment Program of Global Experts Project, Shanghai Municipal Science and Technology Major Project [2018SHZDZX05]
- National Natural Science Foundation of China [31871052]
The study found that visual threats trigger escape and freezing behaviors in mice, which are closely related to a specific type of RGC cell and the Kcnip2 molecular marker, emphasizing that visual information is encoded as early as in the retina.
Animals respond to visual threats, such as a looming object, with innate defensive behaviors. Here, we report that a specific type of retinal ganglion cell (RGC), the OFF-transient alpha RGC, is critical for the detection of looming objects. We identified Kcnip2 as its molecular marker. The activity of the Kcnip2-expressing RGCs encodes the size of the looming object. Ablation or suppression of these RGCs abolished or severely impaired the escape and freezing behaviors of mice in response to a looming object, while activation of their somas in the retina, or their axon terminals in the superior colliculus, triggered immediate escape behavior. Our results link the activity of a single type of RGC to visually triggered innate defensive behaviors and underscore that ethologically significant visual information is encoded by a labeled line strategy as early as in the retina.
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