Recent development in biological activities and safety concerns of perillaldehyde from perilla plants: A review

Monoterpene Perillaldehyde (PAE) is a major component of the essential oil extracted from perilla plants (Perilla frutescens), which has been used as a leafy vegetable and a medicinal agent. PAE has gained a lot of attention in recent years because of its antifungal and other microbial activities and, human health benefits. PAE has also been used as food additives, perfume ingredients, and traditional medicine concoctions. Biological analyses of PAE have revealed that it has good antioxidant activities and can serve as organic fruit and food preservative. Animal studies indicated potent anticancer, anti-depressant, and anti-inflammatory effects of PAE. Also, PAE is certified generally recognized as safe (GRAS) and not mutagenic. However, moderation during usage is advisable, as minor adverse effects are associated with a very high dosage. Despite the newly reported findings, its properties have not been thoroughly summarized and reviewed. Also, clinical trials and official large-scale field applications of PAE in the agricultural sectors are yet to be reported. In this review, updated PAE research progress was provided, focusing on its antifungal and other antimicrobial properties and the mechanisms behind it, phytochemical profile, pharmacological effects, and safety concerns.

Automated summary

Perillaldehyde (PAE), a major component of perilla plants, has antifungal and antimicrobial properties, as well as potential health benefits. It is used in various industries including food, perfume, and traditional medicine. Animal studies have shown PAE's anticancer, anti-depressant, and anti-inflammatory effects, but caution is advised due to potential adverse effects at high doses. Further research and clinical trials are needed to fully understand its properties and potential applications.