期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 62, 期 22, 页码 6225-6237出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2021.1898336
关键词
Diet; animal protein; gut microbiota; disease
资金
- Natural Science Foundation of Hunan Province [2020JJ4138]
- Hunan Furong Scholars Program
- Huxiang Youth Talents Supporting Program [2016RS3033]
- National Natural Science Foundation of China [31771918]
- Scientific Research Foundation of Hunan Provincial Education Department [18A160]
- Grain-oil Process and Quality Control 2011 Collaborative and Innovative Grant from Hunan Province
The role of intestinal flora in health and disease is a hot research topic. High-protein diets (HPDs) may increase the risk of certain diseases, particularly with long-term consumption. Short-term HPDs have minimal impact on healthy individuals under 65 but may be more challenging for those over 65 to meet protein needs.
The role of the intestinal flora in health and disease has become a research hotspot. Compared with carbohydrates and fats, proteins are metabolized primarily by microbial fermentation in the intestine. The production of protein fermentation products and metabolites depends on the composition, diversity, and metabolism of the gut microbiota. Several protein fermentation products, including indoles, phenols, polyamines, hydrogen sulfide (H2S), amines, and carnitine, are toxic. This study analyzes the relationship between high-protein diets (HPDs), the intestinal microbiota, and human health and disease. Long-term HPDs increase the risk of intestinal diseases, type 2 diabetes (T2DM), obesity, central nervous system (CNS) diseases, and cardiovascular diseases (CVD) by producing toxic metabolites in the colon, including amines, H2S, and ammonia. Short-term HPDs have little effect on the metabolism of healthy individuals under 65 years old. However, meeting the protein requirements of individuals over 65 years old using HPDs is more challenging. The adverse effects of HPDs on athletes are minimal. Natural compounds (plant extracts, whose main constituents are polysaccharides and polyphenols), prebiotics, probiotics, and regular physical exercise improve gut dysbiosis and reduce disease risk.
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