Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome

MicroRNA-target networks are often dysregulated in diseases. Our purpose is to investigate this dysregulation of polycystic ovary syndrome (PCOS). Through the bioinformatics reanalysis of the public RNAseq dataset, we found that miR-188-3p was the miRNA with the highest induction rate, and indicated that miR-188-3p might have a rare function of upregulating its targeted expression. This discovery will increase our understanding of the pathology of PCOS and provide new targets for treatment strategies.

Automated summary

The study found that miR-188-3p may have a rare function of upregulating its targeted gene expression in PCOS, providing new insights into the pathology of the disease and new targets for treatment strategies.