期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
卷 242, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpc.2020.108936
关键词
Ciprofloxacin; Chlortetracycline; Ceftazidime; Memory; Aggression
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior Brasil (CAPES) [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [420695/2018-4]
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul [17/2551-0000977-0]
- Instituto Nacional de Ciencias e Tecnologia para Doencas Cerebrais, Excitotoxicidade e Neuroprotecao
- PNPD fellowship from CAPES
- CNPq [304450/2019-7]
Antibiotics are widely used in human and veterinary health along with the food industry, resulting in their presence as contaminants in water bodies. This study reveals that exposure to certain antibiotics led to hyperlocomotion, cognitive decline, and exacerbated aggressive behavior in adult zebrafish, indicating a short-term impact on their behavior.
Antibiotics are widely used drugs in human and veterinary health as well as in the food industry. The majority of these compounds are, however, excreted unchanged and found as contaminants in water bodies. Although the toxicity of these drugs was previously studied in aquatic organisms, the behavioral effects of these pollutants have not been fully explored. Here we exposed adult zebrafish to environmentally relevant concentrations of different classes of antibiotics (Chlortetracycline, Ciprofloxacin, and Ceftazidime) and assessed zebrafish exploratory, cognitive, aggressive, and social behaviors. Ciprofloxacin, Chlortetracycline, and Ceftazidime exposure induced hyperlocomotion, which was characterized by an increase in the distance traveled in zebrafish. These antibiotics promoted cognitive decline and exacerbated aggressive behavior. In summary, this study shows that antibiotic contamination may impact zebrafish behavior in a short-time manner.
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