4.7 Article

CAR T cells for T-cell leukemias: Insights from mathematical models

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Summary: Immunotherapies, particularly the use of CAR T cells to treat B-cell malignancies, have shown significant success in targeting cancer cells. A mathematical model describing the time response of leukaemias to CAR T cell injection accounts for various biological processes and predicts the dynamics of different compartments post-injection, emphasizing the potential role of competition between leukaemic and CAR T cells in cancer relapses.

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