期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 615, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2021.126255
关键词
Drug release system; ATP response; ZIF-90; Forster resonance energy transfer
资金
- National Natural Science Foundation of China [22005180]
- Natural Science Foundation of Shandong Province [ZR2019BB027]
This study developed an ATP-triggered drug delivery system based on porous PLGA microspheres, which features controlled drug release, low toxicity and hemolysis, and enhanced fluorescence intensity through energy transfer.
Poly(lactic-co-glycolic acid) (PLGA) based microparticles have been widely applied in drug delivery system, but pristine PLGA particles suffers from low efficiency in release and non-targeted effect for drug delivery system. Inspired by cancer cells environment, we have fabricated an ATP-triggered delivery system based on porous PLGA microspheres covering drug-loaded ZIF-90. The system contains controlled doxorubicin releasing because ZIF-90 nanocrystals are easily collapsed under exposing to high-concentration ATP environment. In addition, ZIF-90@PLGA microparticles also perform low toxicity and 2.37 % hemolysis, and improved fluorescence intensity of doxorubicin by loading riboflavin sodium phosphate benefited from their partial Fo?rster resonance energy transfer. This novel ATP-triggered drug delivery system based on porous PLGA particles could be widely utilized to design effective drug release biomaterials for gastric and lung cancer.
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