ATP-triggered drug release system based on ZIF-90 loaded porous poly (lactic-co-glycolic acid) microspheres

Poly(lactic-co-glycolic acid) (PLGA) based microparticles have been widely applied in drug delivery system, but pristine PLGA particles suffers from low efficiency in release and non-targeted effect for drug delivery system. Inspired by cancer cells environment, we have fabricated an ATP-triggered delivery system based on porous PLGA microspheres covering drug-loaded ZIF-90. The system contains controlled doxorubicin releasing because ZIF-90 nanocrystals are easily collapsed under exposing to high-concentration ATP environment. In addition, ZIF-90@PLGA microparticles also perform low toxicity and 2.37 % hemolysis, and improved fluorescence intensity of doxorubicin by loading riboflavin sodium phosphate benefited from their partial Fo?rster resonance energy transfer. This novel ATP-triggered drug delivery system based on porous PLGA particles could be widely utilized to design effective drug release biomaterials for gastric and lung cancer.

Automated summary

This study developed an ATP-triggered drug delivery system based on porous PLGA microspheres, which features controlled drug release, low toxicity and hemolysis, and enhanced fluorescence intensity through energy transfer.