4.3 Review

An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer's Disease

期刊

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
卷 21, 期 10, 页码 901-912

出版社

BENTHAM SCIENCE PUBL
DOI: 10.2174/1871527320666210512014505

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Alzheimer's disease; artificial intelligence; biomarkers; algorithms; AD diagnosis; PET

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The treatment of Alzheimer's disease is challenging, mainly due to the difficulty of early diagnosis. Researchers have explored the use of artificial intelligence and technical tools to address this issue, but more data and research are needed.
Background: The complication of Alzheimer's disease (AD) has made the development of its therapeutic a challenging task. Even after decades of research, we have achieved no more than a few years of symptomatic relief. The inability to diagnose the disease early is the major hurdle behind its treatment. Several studies have aimed to identify potential biomarkers that can be detected in body fluids (CSF, blood, urine, etc.) or assessed by neuroimaging (i.e., PET and MRI). However, the clinical implementation of these biomarkers is incomplete as they cannot be validated. Methods: This study aimed to overcome the limitation of using artificial intelligence along with technical tools that have been extensively investigated for AD diagnosis. For developing a promising artificial intelligence strategy that can diagnose AD early, it is critical to supervise neuropsychological outcomes and imaging-based readouts with a proper clinical review. Conclusion: Profound knowledge, a large data pool, and detailed investigations are required for the successful implementation of this tool. This review will enlighten various aspects of early diagnosis of AD using artificial intelligence.

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