Does Human Alpha-Synuclein Behave Like Prions?

Alpha-synuclein (alpha-synuclein) is a protein that is abundantly found in the brain and in a lesser amount in the heart and muscles. The exact role of alpha-synucleinis is not known, but it is considered to control the movement of synaptic vesicles. Its overexpression in the neurons leads to the formation of Lewy bodies that damage the dopaminergic neurons in the subtantianigra of the midbrain and leads to the progression of Parkinson's Disease (PD). There are evidences showing that aggregates of alpha-synuclein behave like prions. The present review is an attempt to put forth the nature of alpha-synuclein as prions.

Automated summary

Alpha-synuclein is a protein abundant in the brain, controlling the movement of synaptic vesicles. Overexpression leads to Lewy body formation and damage to dopaminergic neurons, implicated in the progression of Parkinson's Disease. Aggregates of alpha-synuclein exhibit prion-like behavior.