期刊
CLINICAL ORAL INVESTIGATIONS
卷 25, 期 12, 页码 6769-6777出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00784-021-03964-y
关键词
Head and neck; Oral squamous cell carcinoma; Intraoperative surgical margin control; Intraoperative frozen section analysis; Diagnostic value
资金
- Projekt DEAL
The study evaluated the diagnostic value of intraoperative frozen section analysis in patients with oral squamous cell carcinoma and found that achieving instant R0 status is crucial in reducing disease recurrence and improving patient survival. While IFSA has sensitivity and specificity, it falls short in ensuring secure definite surgical margins.Improved intraoperative diagnostic information on OSCC location and extent could support patient treatment.
Background The objective of this study was to evaluate the diagnostic value of intraoperative frozen section analysis (IFSA) of tumor bed margins in patients with oral squamous cell carcinoma (OSCC). Methods This retrospective study includes 194 primary OSCC cases. The impact of intraoperative information by IFSA on final margin status, local recurrence, and disease-specific survival were analyzed. Results IFSA revealed a 50% sensitivity and a 100% specificity, with a positive and negative predictive value of 100% and 89.1%, respectively. In 19 cases, margins were rated positive by IFSA and remained positive in eight cases (42.1%), despite immediate re-resection. This constellation led to higher recurrence and lower survival rates than in cases with consecutive R0 status (each p = 0.046). Positive margins in IFSA were associated with closer final margins (p = 0.022) and early recurrences (p = 0.050). Conclusions Achieving instant R0 status has a crucial impact on disease recurrence and patient survival. IFSA falls short to ensure secure definite surgical margins. Thus, improved intraoperative diagnostic information on the location and extent of OSCC could support patient treatment.
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