期刊
CLINICAL ORAL INVESTIGATIONS
卷 25, 期 11, 页码 6377-6384出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00784-021-03938-0
关键词
Temporomandibular disorder; Ankylosing spondylitis; Bidirectional analysis; AS; TMD; Population-based
资金
- Ministry of Health and Welfare, Taiwan [MOHW109-TDU-B-212-114004]
- MOST Clinical Trial Consortium for Stroke [MOST 108-2321-B-039-003]
- China Medical University Hospital [DMR-109-126]
- Chang Gung Memorial Hospital [CMRPG3I0152]
- Far Eastern Memorial Hospital [FEMH2021-C-051]
- Tseng-Lien Lin Foundation, Taichung, Taiwan
AS significantly impacts the occurrence of TMD, while TMD may play a synergic role in the development of AS.
Objectives This study aimed to determine the relation between temporomandibular disorder (TMD) and ankylosing spondylitis (AS) bidirectionally and ascertain the important comorbidities for AS occurrence in TMD patients. Materials and methods We conducted this population-based cohort study through Longitudinal Health Insurance Database, Taiwan. Study 1 investigated the risk of TMD in AS patients. Study 2 assessed the risk of AS in TMD patients. Results In total, 3204 AS patients and 12,816 age-matched and gender-matched comparisons were enrolled in study 1. The TMD incidence in the AS cohort was 2.88-fold higher when compared with the comparisons (1.54 vs. 0.53 per 10,000 person-years). After adjusting for age, gender, and comorbidity, the AS cohort had a 2.66-fold (95% CI = 1.79-3.97) increased risk of TMD occurrence (P < 0.0001). The second study recruited 4998 TMD patients and 19,991 age-matched and gender-matched comparisons. Both TMD and comparison cohorts showed similar AS risk (HR = 1.49, 95% CI = 0.91-2.43, P = 0.1108) in the adjusted model. Study 2 identified a 3.66-fold increased risk of AS occurrence in TMD patients with comorbidity, including parapsoriasis, rheumatoid arthritis, osteoporosis, Cushing's syndrome, and climacteric arthritis (P < 0.012). Conclusions AS appears to significantly impact the occurrence of TMD. TMD might play a synergic role in AS development.
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