期刊
CLINICAL NUTRITION
卷 40, 期 4, 页码 2443-2455出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2020.10.050
关键词
Cancer; Cachexia; Skeletal muscle; Myokines; Tumor
资金
- Fundacao de Amparoa Pesquisa do Estado de Sao Paulo (FAPESP), Brazil [2012/50079-0]
- FAPESP, Brazil [2016/13810-9]
- Programa Nacional de Pos-Doutorado/Capes (PNPD/CAPES), Brazil
- FAPESP [2016/02780-1, 2016/12508-7, 2013/25207-7]
- PUB-USP
This study found that the content of myokines in skeletal muscle, plasma, and tumors is impacted by cachexia, with decreased FSTL-1 expression in skeletal muscle and increased levels of FABP3, IL-15, and irisin found in cachectic patients. Additionally, indices of lumbar adipose tissue and muscularity were lower in cachexia patients.
Cancer-associated cachexia is a complex metabolic syndrome characterized by weight loss and systemic inflammation. Muscle loss and fatty infiltration into muscle are associated with poor prognosis in cancer patients. Skeletal muscle secretes myokines, factors with autocrine, paracrine and/or endocrine action, which may be modified by or play a role in cachexia. This study examined myokine content in the plasma, skeletal muscle and tumor homogenates from treatment-naive patients with gastric or colorectal stages I-IV cancer with cachexia (CC, N = 62), or not (weight stable cancer, WSC, N = 32). Myostatin, interleukin (IL) 15, follistatin-like protein 1 (FSTL-1), fatty acid binding protein 3 (FABP3), irisin and brain-derived neurotrophic factor (BDNF) protein content in samples was measured with Multiplex technology; body composition and muscle lipid infiltration were evaluated in computed tomography, and quantification of triacylglycerol (TAG) in the skeletal muscle. Cachectic patients presented lower muscle FSTL-1 expression (p = 0.047), higher FABP3 plasma content (p = 0.0301) and higher tumor tissue expression of FABP3 (p = 0.0182), IL-15 (p = 0.007) and irisin (p = 0.0110), compared to WSC. Neither muscle TAG content, nor muscle attenuation were different between weight stable and cachectic patients. Lumbar adipose tissue (AT) index, visceral AT index and subcutaneous AT index were lower in CC (p = 0.0149, p = 0.0455 and p = 0.0087, respectively), who also presented lower muscularity in the cohort (69.2% of patients; p = 0.0301), compared to WSC. The results indicate the myokine profile in skeletal muscle, plasma and tumor is impacted by cachexia. These findings show that myokines eventually affecting muscle wasting may not solely derive from the muscle itself (as the tumor also may contribute to the systemic scenario), and put forward new perspectives on cachexia treatment targeting myokines and associated receptors and pathways. (c) 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据