期刊
CLINICAL NUCLEAR MEDICINE
卷 46, 期 7, 页码 527-531出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLU.0000000000003662
关键词
F-18-florbetaben (FBB); Alzheimer disease with dementia; amyloid deposition; asymmetry index; mild cognitive impairment; PET
资金
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute - Ministry of Health & Welfare, Republic of Korea [HI18C0460]
- Original Technology Research Program for Brain Science through the National Research Foundation of South Korea (NRF) - Ministry of Science and ICT [NRF-2018M3C7A1057137]
- NRF [2018R1D1A1B07049400, 2018R1D1A1B07045321]
- National Research Foundation of Korea [2018R1D1A1B07049400, 2018M3C7A1057137, 2018R1D1A1B07045321] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study found that the asymmetric pattern of amyloid deposition differs significantly between A beta-negative normal controls and A beta(+) mild cognitive impairment (MCI), and this pattern disappears as the disease progresses.
Purpose In typical Alzheimer disease with dementia (ADD), amyloid pathologies affect both cerebral hemispheres symmetrically. However, the spatial distribution of amyloid-beta (A beta) in the early stage of ADD or over the course of disease has not been investigated. Therefore, we explored asymmetric pattern of A beta deposition in both hemispheres according to the ADD continuum using F-18-florbetaben PET. Methods Sixty-eight subjects, including 15 A beta-negative normal controls, 28 A beta-positive mild cognitive impairment (A beta(+) MCI), and 25 A beta-positive ADD (A beta(+) ADD) subjects, were enrolled. Differences in the asymmetry index and SUV ratio in each of the 6 target regions (4 cortical lobes, cingulate, precuneus) plus composite region between groups were explored. Results The composite and target regional asymmetry indices were significantly different between groups and was highest in A beta(+) MCI (composite, occipital, and temporal, P < 0.001; frontal, P = 0.004). The composite and target regional SUV ratios were significantly different according to 3 groups with gradual increase and were highest in A beta(+) ADD (composite and all target regions, P < 0.001). Conclusions The asymmetric pattern of amyloid deposition was distinct between A beta-negative normal controls and A beta(+) MCI. This pattern disappeared as the disease progressed. These data indicate that asymmetric amyloid deposition may be an early sign of MCI over the course of ADD.
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