期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 27, 期 8, 页码 1158-1166出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2021.04.010
关键词
Community; Coronavirus disease 2019; Death; Hospitalization; Outpatients; Risk factors
资金
- Programme Hospitalier de Recherche Clinique 2020 of the French Ministry of Health
- APHP-Fondation de France
- EIT Health specific Covid-19 fund
This study found that clinical worsening among COVID-19 outpatients is rare, with factors such as male sex, older age, obesity, and comorbidities like chronic renal disease or active cancer independently associated with clinical worsening. However, loss of smell or taste may reduce the probability of worsening.
Objectives: Studies on coronavirus disease 2019 (COVID-19) have mainly focused on hospitalized patients or those with severe disease. We aim to assess the clinical characteristics, outcomes and factors associated with hospital admission or death in adult outpatients with COVID-19. Methods: This is a prospective cohort of outpatients with suspected or confirmed COVID-19, registered in the Covidom telesurveillance solution for home monitoring of patients with COVID-19 in the Greater Paris area, from March to August 2020. The primary outcome was clinical worsening, defined as hospitalization or death within 1 month after symptom onset. Results: Among 43 103 patients, mean age was 42.9 years (SD 14.3 years); 93.0% (n = 40 081) of patients were <65 years old and 61.9% (n = 26 688) were women. Of these 43 103 patients, 67.5% (n = 29 104) completed a medical questionnaire on co-morbidities and symptoms. The main reported co-morbidities were asthma (12.8%; n = 3685), hypertension (12.3%; n = 3546) and diabetes (4.8%; n = 1385). A small proportion of all eligible patients (4.1%, 95% CI 3.9-4.2; 1751/43 103) experienced clinical worsening. The rate of hospitalization was 4.0% (95% CI 3.8%-4.2%; n = 1728) and 0.1% (95% CI 0.1%-0.2%; n = 64) died. Factors associated with clinical worsening were male sex, older age, obesity and co-morbidities such as chronic renal disease or cancer under treatment. Probability of worsening was reduced with anosmia/ ageusia. Conclusions: Clinical worsening was rare among outpatients. Male sex, older age and co-morbidities such as chronic renal disease, active cancers or obesity were independently associated with clinical worsening. However, our cohort may include patients younger and healthier than the general population. Youri Yordanov, Clin Microbiol Infect 2021;27:1158 (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
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