期刊
CLINICAL INFECTIOUS DISEASES
卷 73, 期 11, 页码 2055-2064出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab408
关键词
COVID-19; PASC; probability survey
资金
- Michigan Department of Health and Human Services
- Michigan Public Health Institute
- University of Michigan Institute for Data Science
- University of Michigan Rogel Cancer Center
- University of Michigan Epidemiology Department
The study found that post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) is highly prevalent, especially among cases reporting severe initial symptoms. The prevalence of COVID-19 at 30 and 60 days post-onset was high even among nonhospitalized respondents and those reporting mild symptoms.
Background. Emerging evidence suggests many people have persistent symptoms after acute coronavirus disease 2019 (COVID-19) illness. Our objective was to estimate the prevalence and correlates of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC). Methods. We used a population-based probability survey of adults with COVID-19 in Michigan. Living noninstitutionalized adults aged 18 in the Michigan Disease Surveillance System with COVID-19 onset through mid-April 2020 were eligible for selection (N = 28 000). Among 2000 selected, 629 completed the survey between June-December 2020. We estimated PASC prevalence, defined as persistent symptoms 30 (30-day COVID-19) or >= 60 (60-day COVID-19) days post-COVID-19 onset, overall and by sociodemographic and clinical factors. We used modified Poisson regression to produce adjusted prevalence ratios (aPRs) for potential risk factors. Results. The analytic sample (n = 593) was predominantly female (56.1%), aged >= 45 years (68.2%), and non-Hispanic White (46.3%) or Black (34.8%). Thirty- and 60-day COVID-19 were highly prevalent (52.5% and 35.0%), even among nonhospitalized respondents (43.7% and 26.9%) and respondents reporting mild symptoms (29.2% and 24.5%). Respondents reporting very severe (vs mild) symptoms had 2.25 times higher prevalence of 30-day COVID-19 (aPR, 2.25; 95% CI, 1.46-3.46) and 1.71 times higher prevalence of 60-day COVID-19 (aPR, 1.71; 95% CI: 1.02-2.88). Hospitalized (vs nonhospitalized) respondents had similar to 40% higher prevalence of both 30-day (aPR, 1.37; 95% CI: 1.12-1.69) and 60-day (aPR, 1.40; 95% CI: 1.02-1.93) COVID-19. Conclusions. PASC is highly prevalent among cases reporting severe initial symptoms and, to a lesser extent, cases reporting mild and moderate symptoms.
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